 |
|
 |
Laura J. Sim-Selley,
Ph.D. Associate Professor 1112 East Clay Street McGuire Hall Room 303 P.O. Box 980524 Richmond, Virginia 23298-0524 Phone: (804) 827-0464 E-mail: ljsimsel@vcu.edu Publications: selected | PubMed |
Education: University of Rochester, 1991
Research interests: Functional neuroanatomy of G-protein-coupled receptors, opioid and cannabinoid receptors, tolerance and dependence
My laboratory utilizes a combined neuroanatomical/biochemical pharmacological approach to study G-protein-coupled receptors. The primary receptors of interest are opioid and cannabinoid receptors, although ongoing projects also study monoamine and peptide receptors. Research focuses on the functional neuroanatomy of these systems in the CNS of control animals, as well as animals that have received chronic administration of opioid and cannabinoid drugs. A variety of methods are applied to studying these questions, including agonist-stimulated [ 35 S]GTP gS binding, receptor binding and protein detection using antibodies. These studies are primarily conducted in brain sections, but also can be applied to homogenates of dissected brain regions.
Recent publications:
Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B,
Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley
DE, Sim-Selley LJ, Liu QS, Lichtman AH, and Cravatt BF. (2010) Chronic
monoacylglycerol lipase blockade causes functional antagonism of the
endocannabinoid system. Nat
Neurosci. 13(9):1113-9.
Burston JJ, Wiley JL, Craig AA,
Selley DE, and Sim-Selley LJ. (2010) Regional enhancement of cannabinoid
CB1; receptor desensitization in female adolescent rats following
repeated Delta-tetrahydrocannabinol exposure.
Br J Pharmacol. 161(1):103-12.
Smith TH, Sim-Selley LJ, and
Selley DE. (2010) Cannabinoid CB1 receptor-interacting proteins: novel
targets for central nervous system drug discovery?
Br J Pharmacol. 160(3):454-66.
Nguyen PT, Selley DE,
Sim-Selley LJ. (2010) Statistical Parametric Mapping reveals ligand and
region-specific activation of G-proteins by CB1 receptors and non-CB1
sites in the 3D reconstructed mouse brain.
Neuroimage. 52(4):1243-51.
Hoot MR, Sim-Selley LJ, Poklis
JL, Abdullah RA, Scoggins KL, Selley DE, and Dewey WL. (2010) Chronic
constriction injury reduces cannabinoid receptor 1 activity in the rostral
anterior cingulate cortex of mice.
Brain Res. 1339:18-25.
Falenski KW, Thorpe AJ, Schlosburg
JE, Cravatt BF, Abdullah RA, Smith TH, Selley DE, Lichtman AH, and
Sim-Selley LJ. (2010) FAAH-/- mice display differential tolerance,
dependence, and cannabinoid receptor adaptation after delta
9-tetrahydrocannabinol and anandamide administration.
Neuropsychopharmacology. 35(8):1775-87.
Long JZ, Nomura DK,
Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ,
Lichtman AH, Wiley JL, and Cravatt BF. (2009) Dual blockade of FAAH and
MAGL identifies behavioral processes regulated by endocannabinoid
crosstalk in vivo.
Proc Natl Acad Sci U S A. 106(48):20270-5.
Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL,
Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, and Selley DE.
(2009) Sphingosine-1-phosphate receptors mediate neuromodulatory
functions in the CNS.
J Neurochem. 2009 Aug;110(4):1191-202.