Grants awarded since enactment in 1982 by the Virginia General Assembly
(Code of Virginia, 2.1-373.9).

1982

VCU/MCV Lindon J. Eaves, Ph.D., "Genetic Heterogeneity in Senile and Pre-senile Dementias of the Alzheimer's Type"

VCU/MCV Elizabeth Harkins, Ph.D., "Incidence of Alzheimer's and Related Diseases, Mortality, and Institutionalization among High Risk Elderly Virginians"

1983

UVA H. Robert Brashear, M.D., "Nucleus Basalis Changes in Pick's Disease"

UVA John Savory, Ph.D., "The Effect of Plasma Protein Binding of Aluminum in Altering Permeability of Brain Tissue to Aluminum"

1984

UVA George Alheid, Ph.D., "Heavy Metal Labeling of Ventral Forebrain Neurons"

GMU Jody Bennett, Ed.D., "Needs Assessment of Persons with Alzheimer's Disease"

1985

VCU/MCV George DeVries, Ph.D., "Relationship of Axolemmas Antibody Induced Neuropathology to Alzheimer's Disease"

UVA Ivan S. Login, M.D., "Cortical Deficiency of Somatostatin in Alzheimer's Disease: Effects on Biochemistry and Physiology"

UVA Eric W. Lothman, M.D., Ph.D., "In Vitro Studies of Functional Properties of Basal Forebrain Cholinergic Neurons"

UVA John Savory, Ph.D., "Alzheimer's Disease Neuropathology: Development of an In Vitro Model of Cytoskeletal Changes"

1986

Va Tech William Blaker, Ph.D., "The Role of Axonally Transported Phospholipids in the Synthesis of Acetylcholine"

VCU/MCV Vincent Calabrese, M.D., "Immunologic Response in Dementia of the Alzheimer's Type"

VCU Barbara Myers, Ph.D. and Gary Creasy, Ph.D., "Alzheimer's Disease: Effects on Child and Family Life"

VCU/MCV Iris Parham, Ph.D. and Joan Wood, Ph.D., "Ethnic and Cultural Issues in Family Caregiving"

EVMS Patricia Williams, Ph.D., "Abnormal Calcium Uptake as Expressed by Fibroblasts from Patients with Alzheimer's Disease"

1987

VCU/MCV Lorna M. Barrell, Ph.D., R.N., "Needs Assessment of Persons with Alzheimer's Disease and Their Family Caregivers"

VCU/MCV Richard A. Glennon, Ph.D., "Discriminative Stimulus Properties of the Psychogeriatric Agent Pramiracetam in Rats"

VCU/MCV Susan E. Robinson, Ph.D., "Regulation of Basal Forebrain Cholinergic Neurons"

UVA John Savory, Ph.D., "Effect of Aluminum on Amyloid Gene Expression in a Rabbit Model for Alzheimer's Disease"

EVMS Patricia B. Williams, Ph.D., "Mechanism for Abnormal Calcium Uptake by Fibroblasts from Patients with Alzheimer's Disease"

1988

Va Tech William D. Blaker, Ph.D., "The Influence of Cholinergic Afferents on the Somatostatinergic System in the Rat Hippocampus"

UVA Lennart Heimer, M.D., "Degeneration of Higher Order Olfactory Pathways in Alzheimer's Disease"

VCU/MCV Alfred J. Richard, Ph.D., "The Interactions of THA with DNA as a Function of Ionic Strength and Drug Concentration"

UVA Claire Levesque, M.D., "Quantitative Autoradiographic Analyses of Changes in Cholinergic Markers in Alzheimer's Disease and Aging"

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1989

VCU/MCV Donald J. Abraham, Ph.D., "Specific Ligands for Alzheimer's Disease Beta-Amyloid Protein"

UVA Felicia Gaskin, Ph.D., "Comparison of Antibodies in Alzheimer's Disease and Down's Syndrome"

VCU/MCV Heidi F. Villanueva, Ph.D., "Blockade of AF64A (Ethylcholine Aziridinium Ion) - Induced Memory Impairment in Rats via Pretreatment with Cholinergic Agonists"

UVA Michael R. Wills, M.D., Ph.D., "Aluminum-Induced Neurofibrillary Pathology - Similarities to Human Motoneuron Disease"

1990

VCU/MCV James M. Collins, Ph.D., "Altered Membrane Fluidity of Peripheral Blood Cells of Alzheimer's Disease"

VCU/MCV Linda M. Dougherty, Ph.D. and Joan B. Wood, Ph.D., "Emotional & Personality Factors Related to Caregivers' Adaptation"

UVA Carol A. Manning, Ph.D., "Glucose Enhancement of Memory in Patients with Alzheimer's Disease"

EVMS Bruce W. Tedeschi, Ph.D. and Francis J. Liuzzi, Ph.D., "The Effects of Amyloid-Associated Protease Inhibitors on Neuronal Pathology"

1991

VCU Joyce O. Beckett, Ph.D., "Family Care of African-Americans with Dementia"

Western State Hospital Bernice A. Marcopulos, Ph.D. and David Steiner, M.D., "Periodicity of Agitated Behaviors in Patients with Alzheimer's Disease and Related Disorders: Relationship to Circadian Change in Cognition, Physiological Variables, and Environmental Milieu"

VCU/MCV Glenn C. Van Tuyle, Ph.D., "Accumulation of Partially Deleted DNA as a Basis for Aging and Aging-Related Diseases"

VCU/MCV Robert K. Yu, Ph.D. and Megumi Saito, M.D., Ph.D., "Ganglioside Changes in Alzheimer's Brain"

1992

UVA Daniel J. Cox, Ph.D., "The Presence and Progression of Driving Disability in Alzheimer's Disease Patients"

Family Respite Center Lin E. Noyes, RN, MSN and Shelley K. Gardner, M.A., NHA, "Measuring the Effectiveness of a Supervised Practicum as an Adjunct to Training Family Caregivers"

UVA John Savory, Ph.D., "Reversal of Al-induced Neurodegeneration by Desferrioxamine"

UVA Patricia A. Trimmer, Ph.D., "Regulation of Astocyte Gene Expression in Young Adult and Aged Rats in Response to Neuronal Degeneration"

1993

UVA Shelley Halpain, Ph.D., "Regulation of TAU Phosphorylation in Intact Neurons"

UVA Suzanne Holroyd, M.D., "A Pilot Study of Visual Hallucinations in Patients with A.D."

VCU/MCV Susan Robinson, Ph.D., "Role of Nicotine Receptors in the Regulation of Cholinergic Neurons"

EVMS Bruce Tedeschi, Ph.D., "Does the Amyloid Peptide (A4B) Have Molecular Associations with Heat Shock Chaperone Proteins?"

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1994

VCU/MCV Marc W. Fariss, Ph.D., "Tacrine-Mediated Hepatotoxicity: Role of Protein Synthesis Inhibition"

UVA Samuel A. Green, Ph.D., "Rapid Constitutive Lysosomal Targeting of Amyloid Precursor Protein"

Va Tech Bradley G. Klein, Ph.D., "Glia-derived Trophic Cytokines Associated with Alzheimer's Disease: Neuroplasticity as a Putative Precursor to Neuropathology"

UVA Daniel B. Willingham, Ph.D. & Carol Manning, Ph.D., "Motor Skill in Alzheimer's Disease"

1995

VCU/MCV John W. Bigbee, Ph.D., "Studies on Possible Neurotoxic Effects of Acetylcholinesterase Inhibitors Used in Alzheimer's Disease Treatment"

UVA Heidi Scrable, Ph.D., Shelley Halpain, Ph.D. and David Brautigan, Ph.D., "Investigation into the Role of PP2A in Alzheimer's-like Cytoskeletal Alterations Using a Novel Inducible Gene Expression System"

UVA Patricia A. Trimmer, Ph.D., "Reactive Astrocytes in Aging and Alzheimer's Disease: Neurotrophic Factors"

VCU/MCV Richard B. Westkaemper, Ph.D., "Molecular Models of the Nicotinic Receptor: A Potential Route to the Rational Design of Agents to Treat Alzheimer's Disease"

1996

EVMS Frank J. Castora, Ph.D., "Analysis of the Role of Mitochondrial DNA in Alzheimer's Disease Using mtDNA-Depleted Cells"

DEPT. EMERG. SRVCS. Robert J. Koester, M.S., "Behavioral and Statistical Profile of Lost Alzheimer's and Related Diseases Subjects in Virginia"

UVA John Savory, Ph.D., "Amyloid Precursor Protein and Tau Aggregation in Neuritic Tangles in Aging"

UVA Daniel B. Willingham, Ph.D., "Intrapatient Variability in Alzheimer's Disease"

1997

UVA Thomas C. Foster, Ph.D., "Mechanism for Memory Impairment and Pathophysiology Associated with Aging and Alzheimer's Disease"

EVMS Evan T. Keller, D.V.M., Ph.D. and Paul F. Aravich, Ph.D. (Deptartment of Anatomy and Neurobiology), "Do Free Radicals Induce Interleukin-6 Expression in the Rat Hippocampus? A Model for Alzheimer's Disease"

EVMS Francis J. Liuzzi, Ph.D., "Does Estrogen Protect Basal Forebrain Neurons from Neurodegenerative Changes?"

UVA Russel H. Swerdlow, M.D., "Cytochrome Oxidase Associated Pathophysiology in Alzheimer's Disease"

1998

VCU J. James Cotter, Ph.D., "Special Care for Persons with Alzheimer's Disease and Related Disorders: The Response of Virginia's Nursing Facilities, Adult Care Residences and Home Care Agencies"

Va Tech Bradley G. Klein, Ph.D., and Jeffrey Bloomquist, Ph.D., "Improved Visualization and Localization of the Neural Substrates of Experimental Parkinsonism"

UVA Carol A. Manning, Ph.D., and J. Hunter Downs, III, Ph.D., "Brain Effect of Glucose Facilitation on Memory in Alzheimer's Disease: A Functional Magnetic Resonance Imaging Study"

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1999

GMU Giorgio Ascoli, Ph.D. "Effect of Dendritic Morphology on Neuronal Electrophysiology in a Lesion Model of Alzheimer's Disease"

UVA Suzanne Holroyd, M.D. and Andrew Wolf, M.D. "Attitudes on Whether Physicians Should Tell Alzheimer's Disease Patients Their Diagnosis"

Va Tech Shannon E. Jarrott, Ph.D. "The Effects of Instrumental Assistance on Family Caregivers of Patients with Dementia"

UVA Virginia Simnad, M.D. "Alteration in Proton Spectra of the Hippocampus to Oral Ingestion of Glucose in Alzheimer's Disease"

VCU Patricia W. Slattum, Pharm.D., Ph.D. and Vivien E. James, Pharm.D. "Anticholinergic Medication Use in Elderly Patients Diagnosed with Dementia or Taking Acetylcholinesterase Inhibitors"

2000

UVA James P. Bennett, Jr., M.D., Ph.D. & Christine Thiffault, Ph.D. "Mitochondria Membrane Potential in Alzheimer's Disease"

Goodwin House Sheila Caswell, Mary A. Corcoran, Ph.D, O.T.R., & Karen Love, B.S., "A Staff-Developed Program to Enhance Care Quality for Residents with Dementia"

EVMS Barbara Freund, Ph.D., R.N. "Use of the Clock Drawing Test as a Screen for Declining Driving Competency in Cognitively Impaired Older Adults"

VCU/MCV Mohammed Kalimi, Ph.D. "Amyloid Beta Protein-Induced Hippocampal Cell Death: Mechanism of Action"

VCU/MCV Elizabeth O'Keefe, M.D., Pamela Parsons, G.N.P., & Peter Boling, M.D. "Percutaneous Endoscopic Gastrostomy (PEG) for Nutritional Support in Persons with Advanced Dementia and Feeding Difficulties: Do the Outcomes Fulfill the Expectations of the Decision-Maker?"

Va Tech Sherry Schofield-Tomschin, Ph.D. & Anna Marshall-Baker, Ph.D. "Tactile and Visual Stimuli in Alzheimer's Care Units: Incorporating Quilts in the Living Environment"

2001

UVA Erik J. Fernandez, Ph.D."Revealing Amyloid-ß Structure and Oligomer Distributions Using Mass Spectrometry"

UVA Carol Manning, Ph.D. and Kathleen Fuchs, Ph.D. "The Subjective and Objective Experience of Women at Genetic Risk for Alzheimer's Disease"

UVA John Savory, Ph.D. and Othman Ghribi, Ph.D. "Stress in the Endoplasmic Reticulum Mediates Active Neuronal Death in Experimental Neurodegeneration"

VCU/MCV Jurgen Venitz, M.D., Ph.D. and Yuxin Men, M.D. Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of the Interaction of IV Scopolamine and Physostigmine in Healthy Elderly Volunteers"

VCU/MCV Janet H. Watts, Ph.D., O.T.R. and Jodi L. Teitelman, Ph.D. "Alzheimer's Disease Caregiver Occupational Performance, Respite as a Mental Break, and Program Implications"

2002

Va Tech Paul R. Carlier, Ph.D. "Structure-Based Design of Dimeric Memory Enhancing Drugs"

VCU J. James Cotter, Ph.D., E. Ayn Welleford, Ph.D. and K. Vesley "Improving the Capacity of Home Care Aides in Rural Areas Serving Persons with Alzheimer’s Disease and Related Disorders"

JMU Merle E. Mast, Ph.D. and Marylin Wakefield, Ph.D. "Rural Family Caregivers’ Perceptions of Facilitators and Deterrents to the Use of In-Home Respite"

UVA Elana Farace, Ph.D. and Mark E. Shaffrey, M.D "Neurocognitive Discrimination of Alzheimer's from Normal Pressure Hydrocephalus Verified by Brain Biopsy"

Mountain Empire Older Citizens, Inc. Marilyn Pace Maxwell, M.S.W. and Michael Creedon, D.S.W "Using the Internet for Alzheimer’s Care: The Challenge for Elders and Service Organizations in Approach"

2003

UVA James P. Bennett, M.D., Ph.D. and Bradley Miller, M.D., Ph.D. "Mitochondrial DNA Deletions and Mutations in Alzheimer's Disease Brain Neurons"

Va Tech Toni Calasanti, Ph.D. "Gender Differences in Informal Care Work for Persons with Alzheimer's Disease"

Va Tech Shannon E. Jarrott, Ph.D. and P. Diane Relf, Ph.D. "Horticulture Therapy for Persons with Dementia: Replication of a Pilot Study"

ODU Brian K. Payne, Ph.D. and and Randy R. Gainey, Ph.D. "The Social Context of Providing Care to Alzheimer's Patients: Specifying Interactions Between Social Disorganization, Service Utilization, Burden, and Mistreatment

2004

UVA Kathleen Fuchs, Ph.D. "Beyond Memory Impairment in MCI: Executive Abilities and Implications for Functioning"

UVA David S. Geldmacher, M.D. "Eye-Movement Approaches to Information Processing Abnormalities in Mild Cognitive Impairment"

Va Tech Anne Glass, Ph.D. "The End-of-Life Care Experience for Alzheimer's Patients and Their Families"

Mountain Empire Older Citizens, Inc. Marilyn Pace Maxwell, M.S.W. and Michael Creedon, D.S.W "Developing, Implementing, and Evaluating Training Modules for High School Students to Teach Alzheimer's Caregivers to Use the Internet Effectively as a Tool to Assist in Caring for Their Family Members"

2005

GMU Jane Flinn, Ph.D. "The Effect of Enhanced Levels of Zinc and Iron in Drinking Water on Memory, Amyloid Configuration, and Plaque Development in Transgenic Mice"

GMU Pamela M. Greenwood, Ph.D. & Karl Fryxell, Ph.D. "Use of Allelic Association to Study the Genetics of Cognitive Aging"

College of William and Mary Christine J. Jensen, Ph.D. and colleagues "Promoting an Effective Partnership between Families Coping with Alzheimer's Disease and Their Healthcare Providers"

UVA Michelle King, Ph.D. "Direct Interactions between Aß and Tau in Cultured Cells"

Va Tech Bradley G. Klein, Ph.D. & Jeffrey R. Bloomquist, Ph.D. "Modulation of Cognitive Sequelae of Parkinsonism by Environmental Manganese: Implications for Dementia with Lewy Bodies"

UVA Isaac G. Onyango, D.V.M., Ph.D. "Molecular Mechanisms of Neurodegeneration in Alzheimer's Disease"

UVA Heidi Scrable, Ph.D. "Gene Expression Changes in the Aging HPF Axis"

2006

VCU Dusan Bratko, Dr. Sci. "Computer Screening of Amyloidogenic Protein Variants"

EVMS Frank J. Castora, Ph.D. "Effect of T9861C mtDNA Mutation on Cytochrome Oxidase Structure and Function"

ODU Sheri R. Colberg, Ph.D., FACSM and colleagues. "The Relationship among Alzheimer's Disease, Dementia, Diabetes, and Physical Activity Status"

VCU Jeffrey L. Dupree, Ph.D. "Understanding the Role of Sulfatide in Maintaining Viable Neurons in Alzheimer’s Disease"

UVA Paul Freedman, Ph.D., Richard J. Bonnie, LL. B., and Thomas M. Guterbock, Ph.D. "Voting and Dementia in Virginia Long-Term Care Facilities"

UVA Ian G. Macara, Ph.D. and Huaye Zhang, Ph.D. "The Role of Septins in Alzheimer's Disease"

GMU Jeanne Sorrell, Ph.D., R.N. and Catherine J. Tompkins, Ph.D. "Ethics of Respect for Spirituality in Persons Living with Alzheimer's Disease"

2007

VCU Galya R. Abdrakhmanova, M.D., Ph.D. "Novel Epibatidine Analogs as Potential Selective Agonists of α4ß2 nAChRs"

Shenandoah University Mary A. Corcoran, Ph.D., OTR "Caregiving Styles of Adult Children Who Provide Dementia Care"

UVA Erik J. Fernandez, Ph.D. "Designed Peptides as Models for Amyloid ß Toxicity"

VCU Richard A. Glennon, Ph.D. "Positive Allosteric Modulators of Cholinergic Receptors"

UVA Isaac G. Onyango, D.V.M., Ph.D. "Receptor for Advance Glycation End Products (RAGE) and Lipid Rafts Mediate Amyloid ß Neurotoxicity"

2008

Virginia Tech Paul R. Carlier, Ph.D. "Hydroxyethylamine isostere triazole-linked BACE1 inhibitors for Alzheimer's disease"

ODU Gianluca De Leo, Ph.D. "Improving quality of life and short-term memory loss in patients with Alzheimer's dementia: Smartphone application for capturing daily life moments"

UVA Manoj K. Patel Ph.D. "Cleavage of sodium channel ß3 subunit by BACE1 and γ-secretase modulates sodium channel activity in brain neurons"

Virginia Tech Karen A. Roberto, Ph.D., Rosemary Blieszner, Ph.D., and Jyoti Savla, Ph.D. "Caring for a spouse with Mild Cognitive Impairment: Daily challenges, marital relations, and physiological indicators

UVA Timothy Salthouse, Ph.D. "Detection of preclinical Alzheimer's disease"

UVA Shijun Zhang, Ph.D. & Tailiang Guo, Ph.D. "Bivalent ligands targeting amyloid-ß-peptide and lipid rafts"

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