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S. Stevens
Negus, Ph.D. Professor 410 North 12th Street R. Blackwell Smith Building Room 760B P.O. Box 980613 Richmond, Virginia 23298-0613 Phone: (804) 828-3158 Fax: (804) 828-2117 E-mail: ssnegus@vcu.edu Publications: selected | PubMed |
Education: University of North Carolina, Neurobiology, Ph.D. 1990
Research interests:
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Pharmacology of the analgesic and abuse-related effects of opioid analgesics
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Development of medications to treat opioid and CNS stimulant addiction
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Development of novel procedures to assess analgesia and drug reinforcement
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Strategies for assessment of drug interactions
Morphine-like opioid drugs are
widely used to treat strong pain, but their use is limited by side effects
that include high abuse liability. Our laboratory is engaged in research to
study factors that influence these pain-killing and abuse-related effects of
opioids. Our studies are giving us new insights into the mechanisms and
potential interactions of pain and addiction, and we are also pioneering new
strategies for development of safer analgesics with reduced abuse liability.
This central theme of our work has also stimulated research in three other
directions. First, we are working with medicinal chemistry colleagues to
develop new medications that might be used to treat abuse of opioids and of
CNS stimulants like cocaine. Second, we are developing novel and more
sophisticated procedures to measure behaviors related to pain and addiction.
Finally, our work has led us to develop and refine experimental strategies
for the study of drug interactions.
Recent publications:
Banks ML, Roma PG, Folk JE, Rice KC, and Negus SS. (2011)
Effects of the delta-opioid agonist SNC80 on the abuse liability of
methadone in rhesus monkeys: a behavioral economic analysis.
Psychopharmacology (Berl). [Epub ahead of print]
Newman JL,
Negus SS, Lozama A, Prisinzano TE, and Mello NK. (2010) Behavioral
evaluation of modafinil and the abuse-related effects of cocaine in rhesus
monkeys.
Exp Clin Psychopharmacol.18(5):395-408.
Banks ML, Folk JE,
Rice KC, and Negus SS. (2010) Selective enhancement of fentanyl-induced
antinociception by the delta agonist SNC162 but not by ketamine in rhesus
monkeys: Further evidence supportive of delta agonists as candidate
adjuncts to mu opioid analgesics.
Pharmacol Biochem Behav. 97(2):205-12.
Banks ML, Rice KC,
and Negus SS. (2010) Antinociceptive interactions between Mu-opioid
receptor agonists and the serotonin uptake inhibitor clomipramine in
rhesus monkeys: role of Mu agonist efficacy.
J Pharmacol Exp Ther. 335(2):497-505.
Negus SS, Bilsky EJ,
Do Carmo GP, and Stevenson GW. (2010) Rationale and methods for assessment
of pain-depressed behavior in preclinical assays of pain and analgesia.
Methods Mol Biol. 617:79-91.
Jackson KJ, Carroll FI, Negus
SS, and Damaj MI. (2010) Effect of the selective kappa-opioid receptor
antagonist JDTic on nicotine antinociception, reward, and withdrawal in
the mouse.
Psychopharmacology (Berl). 210(2):285-94.
Negus SS,
Morrissey EM, Rosenberg M, Cheng K, and Rice KC. (2010) Effects of kappa
opioids in an assay of pain-depressed intracranial self-stimulation in
rats. Psychopharmacology
(Berl). 210(2):149-59.
Negus SS, Banks ML, Folk JE, and Rice
KC. (2010) Modulation of delta opioid agonist-induced antinociception by
repeated morphine pretreatment in rhesus monkeys.
Life Sci. 86(11-12):385-92.
Banks ML, and Negus SS. (2010)
Effects of extended cocaine access and cocaine withdrawal on choice
between cocaine and food in rhesus monkeys.
Neuropsychopharmacology. 35(2):493-504.
Kimmel HL, Manvich
DF, Blough BE, Negus SS, and Howell LL. (2009) Behavioral and
neurochemical effects of amphetamine analogs that release monoamines in
the squirrel monkey.
Pharmacol Biochem Behav. 94(2):278-84.
Stevenson GW,
Cormier J, Mercer H, Adams C, Dunbar C, Negus SS, and Bilsky EJ. (2009)
Targeting pain-depressed behaviors in preclinical assays of pain and
analgesia: drug effects on acetic acid-depressed locomotor activity in ICR
mice. Life Sci.
85(7-8):309-15.
Pereira Do Carmo G, Folk JE, Rice KC, Chartoff E, Carlezon W,
and Negus SS.
(2009) Effects of the selective delta opioid agonist SNC80 on intracranial
self-stimulation in rats: Comparison to other pharmacological and
non-pharmacological manipulations. Eur J Pharmacol 604:58-65.