William L. Dewey, Ph.D. Professor and Chair 1112 East Clay Street McGuire Hall Room 100C P.O. Box 980613 Richmond, Virginia 23298-0613 Phone: (804) 827-0375 E-mail: wdewey@vcu.edu Publications: selected | PubMed

Education: University of Connecticut, 1967

Research interests:

The research carried out in this laboratory is directed toward elucidating the mechanism of action of drugs of abuse with emphasis on the opioids. The major emphasis has been placed on the study of the underlying mechanisms of opioid tolerance and physical dependence. Methodologies employed in this laboratory include behavioral techniques such as classical pharmacological procedures to measure pain and its alleviation, quantitation of blood flow using laser Doppler methods, and sophisticated neurochemical procedures such as the use of HPLC to separate endogenous opioids, measurements of endogenous neuropeptides and second messengers via radioimmunoassay of free intracellular calcium levels in cells using whole-cell imagining, as well as microfluorimetric techniques.

Selected publications:

McPherson J, Rivero G, Baptist M, Llorente J, Al-Sabah S, Krasel C, Dewey WL, Bailey CP, Rosethorne EM, Charlton SJ, Henderson G, and Kelly E. (2010) μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization. Mol Pharmacol. 78(4):756-66.

Hull LC, Rabender C, Gabra BH, Zhang F, Li PL, and Dewey WL. (2010) Role of CD38, a cyclic ADP-ribosylcyclase, in morphine antinociception and tolerance. J Pharmacol Exp Ther. 334(3):1042-50.

Hoot MR, Sim-Selley LJ, Poklis JL, Abdullah RA, Scoggins KL, Selley DE, and Dewey WL. (2010) Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. Brain Res. 1339:18-25.

Hull LC, Llorente J, Gabra BH, Smith FL, Kelly E, Bailey C, Henderson G, and Dewey WL. (2010) The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy. J Pharmacol Exp Ther. 332(3):1127-35.

Bailey CP, Oldfield S, Llorente J, Caunt CJ, Teschemacher AG, Roberts L, McArdle CA, Smith FL, Dewey WL, Kelly E, and Henderson G. (2009) Involvement of PKC alpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons. Br J Pharmacol. 158(1):157-64.

Bailey CP, Llorente J, Gabra BH, Smith FL, Dewey WL, Kelly E, and Henderson G. (2009) Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons. Eur J Neurosci. 29(2):307-18.

Li G, Aschenbach LC, Chen J, Cassidy MP, Stevens DL, Gabra BH, Selley DE, Dewey WL, Westkaemper RB, and Zhang Y. (2009) Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists. J Med Chem. 52(5):1416-27.

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