||William L. Dewey,
Professor and Chair
1112 East Clay Street
McGuire Hall Room 100C
P.O. Box 980613
Richmond, Virginia 23298-0613
Phone: (804) 827-0375
Publications: selected | PubMed
Education: University of Connecticut, 1967
The research carried out in this laboratory is directed toward elucidating
the mechanism of action of drugs of abuse with emphasis on the opioids. The
major emphasis has been placed on the study of the underlying mechanisms
of opioid tolerance and physical dependence. Methodologies employed
in this laboratory include behavioral techniques such as classical
pharmacological procedures to measure pain and its alleviation, quantitation
of blood flow using laser Doppler methods, and sophisticated neurochemical
procedures such as the use of HPLC to separate endogenous opioids, measurements
of endogenous neuropeptides and second messengers via radioimmunoassay
of free intracellular calcium levels in cells using whole-cell imagining,
as well as microfluorimetric techniques.
McPherson J, Rivero G, Baptist M, Llorente J, Al-Sabah S,
Krasel C, Dewey WL, Bailey CP, Rosethorne EM, Charlton SJ, Henderson G,
and Kelly E. (2010) μ-opioid receptors: correlation of agonist efficacy
for signalling with ability to activate internalization.
Mol Pharmacol. 78(4):756-66.
Hull LC, Rabender C, Gabra BH,
Zhang F, Li PL, and Dewey WL. (2010) Role of CD38, a cyclic
ADP-ribosylcyclase, in morphine antinociception and tolerance.
J Pharmacol Exp Ther. 334(3):1042-50.
Hoot MR, Sim-Selley
LJ, Poklis JL, Abdullah RA, Scoggins KL, Selley DE, and Dewey WL. (2010)
Chronic constriction injury reduces cannabinoid receptor 1 activity in the
rostral anterior cingulate cortex of mice.
Brain Res. 1339:18-25.
Hull LC, Llorente J, Gabra BH, Smith
FL, Kelly E, Bailey C, Henderson G, and Dewey WL. (2010) The effect of
protein kinase C and G protein-coupled receptor kinase inhibition on
tolerance induced by mu-opioid agonists of different efficacy.
J Pharmacol Exp Ther. 332(3):1127-35.
Bailey CP, Oldfield S,
Llorente J, Caunt CJ, Teschemacher AG, Roberts L, McArdle CA, Smith FL,
Dewey WL, Kelly E, and Henderson G. (2009) Involvement of PKC alpha and
G-protein-coupled receptor kinase 2 in agonist-selective desensitization
of mu-opioid receptors in mature brain neurons.
Br J Pharmacol. 158(1):157-64.
Bailey CP, Llorente J, Gabra
BH, Smith FL, Dewey WL, Kelly E, and Henderson G. (2009) Role of protein
kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to
morphine in rat locus coeruleus neurons.
Eur J Neurosci. 29(2):307-18.
Li G, Aschenbach LC, Chen J,
Cassidy MP, Stevens DL, Gabra BH, Selley DE, Dewey WL, Westkaemper RB, and
Zhang Y. (2009) Design, synthesis, and biological evaluation of 6alpha-
and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid
receptor selective antagonists.
J Med Chem. 52(5):1416-27.
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