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Research & Clinical Studies

Our center is currently sponsoring a number of research studies for women with Polycystic Ovary Syndrome (PCOS) and for women with regular menses (normal controls).

If you are interested in more information about or in volunteering for one of these studies, please contact Maria Shulleeta. Compensation is provided for participation for all of the studies.


Pharmacogenetics of Metformin Action in PCOS
VCU IRB# HM 11153
Principal Investigator: John E. Nestler, M.D.

A study for women with PCOS who are 18-45 years old, in good general health and non-diabetic. In this study 36 women will take a 9-month course of metformin (Glucophage). There will be 3 mornings of testing and monthly clinic visits. A blood test will be done to identify specific DNA (genes) that will predict the effect that metformin has on ovulation. This will help us recognize a more efficient and effective treatment of infertility in PCOS. Compensation is $700.

Endothelial Dysfunction in Adolescents and Women with PCOS
VCU IRB# HM14039
Principal Investigator: Edmond P Wickham, M.D

A study for women who are 18-40 years old, non-smoker, in good general health, and non-diabetic.  Both women with regular menstrual periods and women with newly- diagnosed polycystic ovary syndrome (PCOS) may be eligible for study participation.  The study involves one morning of testing (approximately 4 hours). The results of this study will help us determine if women with PCOS have changes in their blood vessels that could lead to irregular menstrual periods. Compensation is $100.

Pregnant Women with Polycystic Ovary Syndrome
VCU IRB# 13733
Principal Investigator: “Annie” Kai I. Cheang, PharmD

If you are 18-40 years old, are currently pregnant, and have polycystic ovary syndrome (8 or fewer menstrual cycles per year) prior to becoming pregnant, you may be eligible to participate in a research study evaluating risk of gestational diabetes. Women with polycystic ovary syndrome may be at a higher risk of developing gestational diabetes during pregnancy.  This study will evaluate factors that may contribute to this risk.  Participants will have their blood sugar and insulin checked during pregnancy.  Study participants will attend 3 visits during their pregnancy to complete questionnaires and have samples of blood drawn. Compensation will be provided. Please call (804)828-9698 if interested.

This study is conducted by Dr. “Annie” Kai Cheang, and Dr. Scott Lucidi at VCU Health System.  The study is supported by the National Institutes of Health.

Birth Control Pill Study
VCU IRB# 13769
Principal Investigator: “Annie” Kai I. Cheang, PharmD

Women volunteers are needed for a research study to evaluate factors when using the pill that may affect how the body handles sugar and heart disease risk profile. Volunteers should be 18-35 years old, do not smoke, and have not been on the pill for the past 3 months. Participants will spend 5 mornings at the VCU Clinical Research Center over 6 months. Compensation and a 6-month supply of a commonly used FDA-approved birth control pill will be provided.  Call 828-9698 if interested.

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Virginia Commonwealth University | Division of Endocrinology & Metabolism | Contact Us
1101 East Marshall Street, PO Box 980111
Richmond, Virginia 23298
(804) 828-9696

Last Updated: February 01, 2007