STUDY
#1:
"Determination if Direct Inhibition of Insulin Release with Diazoxide Decreases Renal Clearance of D-chiro-inositol (DCI) and Increases Circulating DCI in Obese Women with Polycystic Ovary Syndrome (PCOS)"
Principal Investigator: John E. Nestler, M.D. & Edmond Wickham, M.D.
A study for obese women with and without PCOS who are 18–40 years old and in general good health. There will be three morning sessions over a period of 12 days consisting of three hours, half an hour, and three hours respectively. Subjects will be required to take ‘diazoxide’ for ten days. Insulin sensitivity and D-chiro-inositol levels in blood and urine will be measured. Subjects must be fasting overnight for the first and third visits. Compensation is $300.
STUDY
#2:
"Combination Metformin and Oral Contraceptive for Polycystic Ovary Syndrome"
Principal Investigator: Paulina A. Essah, M.D.
IRB # 3879
A study for obese women with PCOS who are 18-45 years old and in general good health and non-diabetic. In this study, 28 women with PCOS will be randomized to a 3-month course of either an oral contraceptive pill (Ortho-TriCylen) or a combination of an oral contraceptive pill and metformin (Glucophage). There will be four mornings of testing. Insulin sensitivity, blood tests for cardiovascular risk, and a noninvasive test for blood flow will be performed. Compensation is $400.
STUDY
#3:
"Oral Contraceptives in the Metabolic Syndrome"
Principal Investigator: “Annie” Kai I. Cheang, Pharm.D.
IRB # 4060
A study for overweight or full-figured women general good health and non-diabetic. The purpose of this study is to see whether the oral contraceptive pill changes how the body handles insulin and glucose. In this study, 20 women will take an oral contraceptive pill (Ortho-TriCylen) for 6 months. There will be five mornings of testing. Insulin sensitivity, and blood tests for cardiovascular risk will be performed. Compensation is $400.
STUDY
#4:
Women volunteers needed
Principal Investigator: “Annie” Kai I. Cheang, Pharm.D.
IRB # 4060
The Endocrinology Division at VCU Medical Center is recruiting women volunteers to see whether birth control pills change how the body handles insulin and glucose. You may qualify for this study if you are 18 – 40 years old, and are willing to spend 5 – 6 mornings at the VCU Medical Center. You must not have been on birth control pills for the past three months and are willing to take birth control pills in the study. Volunteers will receive up to $400 for participating in this study. Contact Dr. “Annie” Kai I. Cheang at 804-828-9698 or kicheang@vcu.edu.
STUDY
#5:
"Determination if Indirectly Reducing Circulating Insulin by Improving Insulin Sensitivity with Pioglitazone, Decreases Renal Clearance of DCI, Increases the Circulating Concentration of DCI, and Enhances Insulin-Stimulated Release of the DCI-IPG Mediator in Obese Women with PCOS"
Principal Investigator: John E. Nestler, M.D.
IRB# 4480
A study for women with PCOS in general good health and non-diabetic. The purpose of this study is to see if lowering the amount on insulin in blood by taking pioglitazone will change the levels of DCI. Up to 66 full-figured women with PCOS will participate in this study lasting 6 months. There will be 2 mornings of testing, monthly monitoring visits, daily pill taking, and two mornings of testing at the end of the study. Compensation is $600.
STUDY
#6:
"Determination if Pharmacologic Blockade of Androgen Action Decreases Renal Clearance of DCI, Increases the Circulating Concentration of DCI, and Enhances Insulin-Stimulated Release of the DCI-IPG Mediator in Obese Women with PCOS"
Principal Investigator: John E. Nestler, M.D.
IRB # 4487
A study for women with PCOS in general good health and non-diabetic. The purpose of this study is to see if blocking “male hormones” with a medication lowers the removal of DCI ( a hormone involved in sugar metabolism) ,from the kidneys and increases the amount of DCI in the blood. The study will require 5 morning study session at VCU and that you take a study drug for 4 weeks. Compensation provided.
STUDY
#7:
Weight Loss Study—If you have irregular or infrequent menstrual periods
Principal Investigator: “Annie” Kai I. Cheang, Pharm.D.
IRB # HM10313
You may qualify for this study if you have irregular or infrequent menstrual periods, or have polycystic ovary syndrome. In addition, you should be 18 – 40 years old, have a full-figured or plus-size body, do not have diabetes, and are willing to follow dietary weight loss guidelines for two months with the help of dieticians. You must not have been on birth control pills or metformin for the past three months. This study will involve 5 mornings at the MCV hospital over 8 weeks. There will also be weekly weight checks. Volunteers will receive up to $250 for participating in this study. Contact Dr. Annie Kai I. Cheang at 804-828-9698 or kicheang@vcu.edu.
STUDY
#8:
Weight Loss Study—Full-Figured Women Volunteers Needed!
Principal Investigator: “Annie” Kai I. Cheang, Pharm.D.
IRB #HM10313
You may qualify for this study if you are 18 – 40 years old, have a full-figured or plus-size body, have regular menstrual periods, do not have diabetes, and are willing to follow dietary weight loss guidelines for two months with the help of dieticians. You must not have been on birth control pills for the past three months. This study will involve 5 mornings at the MCV hospital over 8 weeks. There will also be weekly weight checks. Volunteers will receive up to $250 for participating in this study. Contact Dr. Annie Kai I. Cheang at 804-828-9698 or kicheang@vcu.edu.
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