Molecular Cell Biology & Cancer Research Group
Knowing the components of cells and how cells work is fundamental to all biological sciences. There are similarities and differences between cell types, which is particularly important to the fields of cell and molecular biology as well as to biomedical fields such as cancer research and developmental biology. These fundamental similarities and differences can permit the principles learned from studying one cell type to be extrapolated to other cell types. Thus, research in cell biology is closely related to genetics, biochemistry, molecular biology, Immunology and developmental biology.
Oncogenically transformed cells arise through a multistep process, and are normally subject to immune surveillance and elimination by the immune system. Several hereditary factors can increase the chance of cancer-causing mutations, including the activation of oncogenes or the inhibition of tumor suppressor genes. Various oncogenes and tumor suppressor genes can be disrupted at different stages of tumor progression, and mutations in such genes can be used to classify the malignancy of a tumor. The identification of oncogenes and tumor suppressor genes is important to understand tumor progression and treatment success. Much of the research done by this group is focused on understanding the immune mechanisms involved in tumor recognition and rejection, as well as fundamental mechanisms of cellular transformation. Studies include translational research aimed at improving cancer therapeutics and/or cancer vaccines.
Microbiology & Immunology Department Faculty
- Guy A. Cabral, Ph.D.
Viral oncology (herpes virus); Non-A, Non-B hepatitis, the effect of environmental chemicals on virus infections, drugs of abuse and the immune system.
- Gail E. Christie, Ph.D.
Role of bacteriophages in microbial evolution and pathogenesis; regulation of prokaryotic gene expression; RNA polymerase structure and function.
- W. Michael Holmes, Ph.D.
RNA Protein Interactions. RNA Modification, mRNA and MicroRNA Metabolism.
- Phillip B. Hylemon, Ph.D.
Steroid metabolism by intestinal anaerobic gut bacteria, regulation of cholesterol and bile acid synthesis in hepatocyte monolayer cultures.
- Deborah A. Lebman, Ph.D.
The role of alterations in the transforming growth factor beta signaling pathway in the development of upper digestive tract cancers.
- Masoud H. Manjili, Ph.D.
Immunotherapy of breast cancer, tumor escape and antigen loss, myeloid-derived suppressor cell.
- Ronald B. Smeltz, Ph.D.
Immunobiology of Trapanozoma cruzi (euglenoid parasite) infection, CD8+ T cell responses, cytokines, IFN-gamma.
- Shirley M. Taylor, Ph.D.
DNA methylation and control of cell differentiation, allelic inactivation of tumor suppressor genes .
- Huiping Zhou, Ph.D.
The cellular/molecular mechanisms of HIV protease inhibitor-associated dysregulation of lipid metabolism and atherosclerosis.
- Harry D. Bear, M.D. - Surgical Oncology
Tumor immunology, suppressor T cells.
- Jessica Bell, Ph.D. - Biochemistry
Mechanism of ligand recognition by innate immune (Toll-like) receptors and subsequent signal transduction. Implications in adjuvant and chemotherapeutic agent development.
- James C. Burns, DDS, Ph.D. - Chair of Oral Pathology
Oral virology and oral cancer.
- Sumitra Deb, Ph.D. - Biochemistry and Molecular Biophysics
Molecular biology of the human tumor suppressor p53.
- Swati Palit Deb, Ph.D. - Biochemistry and Molecular Biophysics
Growth regulatory mechanisms of normal cells, particularly those deregulated during oncogenesis.
- Gordon D. Ginder, M.D. - Director, Massey Cancer Center
Regulation of genes critical to blood diseases, cancer and lymphocyte effector function by epigenetic mechanisms and interferons.
- Steven Grant, M.D. - Internal Medicine, Hematology/Oncology
Tumor biology. Modulation of anti-leukemic drug action and apoptosis by signal transduction events.
- Chris Kepley, PhD, MBA - Luna nanoWorks
Using endofullerences for imaging atherosclerotic plaque, brain cancers, and neurodegenerative disease. Developing empty-cage fullerene derivatives into therapies for asthma, allergy and arthritis.
- Geoffrey W. Krystal, M.D., Ph.D. - Internal Medicine, Hematology/Oncology
Molecular biology of oncogenes, specifically the regulation of transcription and RNA processing of the myc gene family.
- Luiz Shozo Ozaki, Ph.D. - Bioinformatics & Bioengineering
Comparative genomics for studying pathogenicity and phylogeny of parasitic protozoa.
- Lawrence F. Povirk, M.D. - Pharmacology & Toxicology
DNA damage and mutagenesis, DNA double-strand break repair and gene rearrangements in mammalian cells. Mutagenic effects of DNA-directed chemotherapeutic agents.
- Kristoffer Valerie, Ph.D. - Radiation Oncology
Molecular biology of DNA repair, radiation-induced gene expression and signal transduction mechanisms and genetic approaches to modulate cellular radioresistance.
Relevant Courses Offered
- MICR 505 Immunobiology - A survey of immunobiology as a total host response to foreign agents.
- MICR 686 Advanced Immunology - Topics in tumor immunology, cell interactions and genetics in the immune response.
- MICR 607 Techniques in Molecular Biology and Genetics.
- MICR 605 Molecular Biology and Genetics.
- MICR 653 Advanced Molecular Genetics
- MICR691 Molecular Biology of Cancer
- Immunology Journal Club - Tumor immunology, cell interactions and genetics in the immune response.
- MBG Journal Club - Various topics in molecular biology & genetics.
The Goodwin Research Laboratory at the
VCU Massey Cancer Center opened spring 2006