Charles H. O'Neal, Ph.D.
Associate Professor

Phone: (804) 828-2302
Dept. Fax: (804) 828-9946
e-mail: coneal@vcu.edu

Address:
Department of Microbiology & Immunology
Virginia Commonwealth University
P.O. Box 980678
1101 East Marshall St., 6-038 Sanger Hall
Richmond, VA 23298-0678

Professional Experience

• B.S., 1957, Georgia Institute of Technology
• Ph.D., 1963, Emory University 
• Postdoctoral: 1963-1965, USPHS NIH, Laboratory of Molecular Genetics; 1965-1968, Research Associate & Assistant Professor, The Rockefeller University; 1971-1972, Visiting Scientist, MRC Lab of Molecular Biology, Cambridge University; 1996-1997, Visiting Scientist, Max Planck Institute of Molecular Genetics, Berlin (Dahlem), Germany

Research Interests:

My research interests initially centered on centrifugal isolation of cytologic organelles and their enzymes including ribosomes and polysomes. Later studies consisted of the synthesis of known sequence oligonucleotides by enzymatic and chemical methods for codon elucidation. In recent years, we have investigated and developed procedures for characterization of macromolecules including transient electric birefringence, for size and shape parameters, and countercurrent dialysis for assay of labeled substrates into macromolecules. Other interests have been the isolation and characterization of CType virus from Host vs. Graft (HVG) Syndrome, the role of T-RNA in control processes in a variety of systems including regenerating rat liver and control systems in normal and transformed cell. During the past year, we have carried out crosslinking studies on components of the active site of ribosomal protein systhesis.
 

Selected Publications:

Brinkley, F., N. King, E. Milikin, R. Wright, and C.H. O'Neal. Brush Border Particulate of Renal Tissue. Science 162:1009-1011 (1969).

Nirenberg, M., P. Leder, M. Bernfield, R. Brimacombe, J. Trupin, F. Roftman and C. O'Neal. RNA Codewords and Protein Synthesis VII. On the General Nature of the RNA Code. P.N.A.S. (U.S.) 53:1161-1168 (1965).

Chen, H.C., C.H. O'Neal and L.C. Craig. Rapid Laboratory Dialysis for the Amino Acylation of tRNA. Analytical Chemistry 43:1017-1020 (1970).

Thompson, M.R., R.C. Williams and C.H. O'Neal. Studies on TRNA and Proteins with Transient Electric Birefringence. Biophysical Journal 24:264267 (1978).

An, T., A.J. Aymes and C.H. O'Neal. Natural Clustering of Fc Receptors on Human Neutrophils not affected by the Cytoskeletal Reagents. Immunology 43:505-512 (1981).  

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