Peer-Reviewed Papers

1. Jefferson K. K., S. E. Cramton , F. Götz, G. B. Pier. (2003). Identification of a 5-nucleotide sequence that controls expression of the ica locus in Staphylococcus aureus and characterization of the DNA-binding properties of IcaR. Mol. Microbiol.48(4):889-899.

2. Jefferson K. K., D. B. Pier, D. A. Goldman, and G. B. Pier. (2004). The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus. Journal of Bacteriology.  J. Bacteriol. 186 (8): 2449-2456.

3. Jefferson K. K., D. A. Goldmann, and G. B. Pier. (2005). Use of confocal microscopy to analyze the rate of vancomycin-binding in Staphylococcus aureus biofilms. Antimicrob. Agents Chemother. 49 (6): 2467-2473.

4. Cerca N., Martins S., Cerca F., Jefferson K. K., Pier G. B., Oliveira R., Azeredo J.  (2005). Comparative assessment of the susceptibility of coagulase-negative staphylococcal cells in biofilm versus planktonic culture to antibiotic killing as assessed by bacterial enumeration or rapid XTT colorimetry. J. Antimicrob. Chemother. 56: 331-336.

5. Kropec A., T. Maira-Litran, K. Jefferson, M. Grout, C. Kelly-Quintos, S. Cramton, F. Götz, D. A. Goldmann, G. B. Pier. (2005). Poly-N-acetyl glucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection. Infect. Immun. 73(10):6868-6876.

6. Cerca N., S. Martins, S. Sillankorva, K. K. Jefferson, G. B. Pier, R. Oliveira, J. Azeredo. (2005). How growth in sub-inhibitory concentrations of dicloxacillin affects Staphylococcus epidermidis and Staphylococcus haemolyticus biofilms. Appl. Env. Micro. 71(12):8677-8682.

7. Cerca, N. , K. K. Jefferson, R. Oliveira, G. B. Pier, J. Azeredo. (2006) Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in theplanktonic state. Infect Immun. 74(8):4849-55

8. Cerca N, T. Maira-Litran, K.K Jefferson, M. Grout, D.A. Goldmann, G.B. Pier. (2007) Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide. Proc Natl Acad Sci U S A. 104(18);7528-7533.

9. Cerca N, K.K Jefferson, T. Maira-Litran, D.B. Pier, C. Kelly-Quintos, D.A. Goldmann, J. Azeredo, G.B. Pier. (2007) Molecular basis for preferential protective efficacy of antibodies directed to the poorly-acetylated form of staphylococcal poly-N-acetyl-{beta}-(1-6)-glucosamine. Infect Immun. 75(7) 3406-3413.

10. Patterson, J.L., P.H. Girerd, N.W. Karjane, K.K. Jefferson. (2007). Gardnerella vaginalis to hydrogen peroxide and lactic acid. Amer J Obstet Gyn. 197(2); 170.

11. Cerca, N. K.K.Jefferson (2008). Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli. FEMS Micro Lett. 283 (1):36-41.

12. Cerca, N., J.L. Brooks, and K.K. Jefferson. (2008). Regulation of the intercellular adhesin locus regulator (icaR) by SarA, SigB, and IcaR in Staphylococcus aureus. J. Bacteriol. 190 (19):6530.

13. Mackey-Lawrence, N.M., Potter, D.E., Cerca, N., and Jefferson, K.K. (2009). Staphylococcus aureus Immunodominant Surface Antigen B is a Cell-surface Associated Nucleic Acid Binding Protein. BMC Microbiol. 9:61.

14. Patterson JL, Stull-Lane A, Girerd PH, Jefferson KK. (2010). Analysis of adherence, biofilm formation, and cytotoxicity suggest a greater virulence potential of Gardnerella vaginalis relative to other bacterial vaginosis-associated anaerobes. Microbiology.156(2):392-9.

15. Thompson KM, Abraham N, and Jefferson KK. (2010). Staphylococcus aureus Extracellular Adherence Protein Contributes to Biofilm Formation in the Presence of Serum. FEMS Microbiology Letters. 305(2):143-7.

16. Harwich MD, Alves JM, Buck GA, Strauss JF, Patterson JL, Oki AT, Girerd PH, and Jefferson KK. (2010). Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies. BMC Genomics. 11:375

17. Abraham NM and Jefferson KK. (2010) A low molecular weight component of serum inhibits biofilm formation in Staphylococcus aureus. Microbial Pathogenesis. 49(6):388-91.

18. Guido Lopes dos Santos Santiago, Leen Vancoillie, Piet Cools, Pieter Deschaght, Nabil El Aila, Teresa Kiama, Hans Verstraelen, Rita Verhelst, Kimberly K. Jefferson, Marleen Temmerman, Mario Vaneechoutte. (2011) Gardnerella vaginalis comprises three distinct genotypes of which only two produce sialidase. American Journal of Obstetrics and Gynecology. American J Obstetrics and Gynecology [Epub ahead of print].

19. Abraham NM, Lamlertthon S, Fowler VG Jr, Jefferson KK. (2012). Chelating agents exert distinct effects on biofilm formation in Staphylococcus aureus depending on strain background: role for Clumping factor B. J Med Microbiol. [Epub ahead of print]

20. Abraham NM, Jefferson KK. (2012). Staphylococcus aureus clumping factor B mediates biofilm formation in the absence of calcium. Microbiology. [Epub ahead of print]

21. Michael D. Harwich Jr., Myrna G. Serrano, Jennifer M. Fettweis, João M.P. Alves , Mark A. Reimers, Vaginal Microbiome Consortium (additional members), Gregory A. Buck, and Kimberly K. Jefferson. (2012). Genomic sequence analysis and characterization of Sneathia amnii sp.nov. BMC Genomics. (In Press).

22. Fettweis JM, Serrano MG, Girerd PH, Jefferson KK, Buck GA. (2012). A new era of the vaginal microbiome: advances using next-generation sequencing. Chemistry and Biodiversity.  9(5):965-76.


1. Jefferson K. K. and G. B. Pier. Pseudomonas aeruginosa biofilms. (2003) In: Medical Implications of Biofilms (M Wilson, D Devine, eds.). Cambridge University Press. pp. 287-310.

2. Jefferson K. K. (2004). What drives bacteria to produce a biofilm? FEMS Microbiol. Lett. 236 (2): 163-173.

3. Jefferson K. K. and Cerca N. (2005). Bacterial-bacterial cell interactions in biofilms: Detection of polysaccharide intercellular adhesins by blotting and confocal microscopy. Methods Mol Biol. 341:119-26.

4. Thompson, K.M. and K. K. Jefferson. (2008). Adaptation to Stress: Biofilms and Small Colony Variants. In: Staphylococci in Human Disease (K. Crossley, G.A. Archer, V. Fowler, and K.K. Jefferson, eds). Blackwell Publishing.  

5. Jefferson K. K. (2009). Poly-N-acetyl-glucosamine as a mediator of bacterial biofilm formation. In: Bacterial polysaccharides – Current innovations and future trends (Mathias Ullrich, ed.). Horizon Press.

6. Jefferson K.K. (2012). The bacterial etiology of preterm birth.  Adv App Microbiol (In press).

Lab Home | Research | People | Publications| Contact Us

Back to top

VCU Department of Microbiology and Immunology Virginia Commonwealth University VCU Medical Center
Video Gallery 06