Hsiu-Sheng Hsu , Ph.D.
Professor

Phone: (804) 828-2302
Dept. Fax: (804) 828-9946
e-mail: hsu@vcu.edu

Address:
Department of Microbiology & Immunology
Virginia Commonwealth University
PO Box 980678
1101 East Marshall Street, 6-038 Sanger Hall
Richmond, VA 23298-0678

Professional Experience

• B.Sc., 1955, McGill University 
• Ph.D., 1959, University of Pennsylvania 
• Postdoctoral: 1959-1962, University of Pennsylvania;1963-1964, Johns Hopkins Medical School

Research Interests:

Mouse typhoid is used as an experimental model to study the mechanisms of pathogenesis and host resistance in bacterial infections. Based on our in vitro and in vivo observations, virulent salmonellae are killed within inflammatory polymorphs and macrophages of mice. In a systemic disease, the pathogen propagates primarily in the extracellular locations of sinusoids and tissue lesions and within hepatocytes. Histopathological evidence also shows its passage through the biliary system to the gallbladder. Acquired immunity to the disease is a synergistic response of antibodies and delayed hypersensitivity to the bacterial antigens, which provides the basis for the development of vaccines against the infection. From our study, an analogy of pathogenesis can be drawn between mouse typhoid and human typhoid fever. Current research is directed toward the understanding of genetic basis of host resistance to the infection.
 

Selected Publications:

Lin, F.R., X.M. Wang, H.S. Hsu, V.R. Mumaw and 1. Nakoneczna. Electron microscopic studies on the location of bacterial proliferation in the liver in murine salmonellosis. Brit. J. Exp. Path. 68:539550 (1987).

Lin, F.R., H.S. Hsu, V.R. Mumaw and C.W. Moncure. Confirmation of destruction of salmonellae within murine peritoneal exudate cells by immunocyto-chemical technique. Immunology 67:394-400 (1989).

Hsu, H.S. Pathogenesis and immunity in murine salmonellosis. Microbiol. Rev. 53:390-409 (1989).

Ding, H.F., 1. Nakoneczna and H.S. Hsu. Protective immunity induced in mice by detoxified Salmonella lipopolysaccharide. J. Med. Microbiol. 31:95-102 (1990).

Xu, H.R., Y.Y. Tan, H.S. Hsu., C.W. Moncure, and X.M. Wang Comparative antibody response to salmonella antigens in genetically resistant and suscetible mice. Clin. Exp. lmmunol., 91:73-77 (1993).

Hsu, H.S. Is Salmonella an intracellular pathogen. In F.C. Cabello and C.E. Hormaeche (ed), "The Biology of Salmonella". Plenum Publishing Corp. New York (1993).

Moncure CW, Guo YN, Xu HR, Hsu HS. Comparative histopathology in mouse typhoid among genetically diverse mice. Int J Exp Pathol. 1998 Jun;79(3):183-92.

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