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Center for the Study of Biological complexity
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Research Program & Partnerships

Research Foci

The unifying vision of the Center focuses on the application of the principles of complexity to the understanding of life that has been derived from the successes of deciphering genomes, proteomes, transcriptomes and metabolomes. Biological complexity research extends the tenets of discovery science and systems biology by espousing the principle that life is complex, meaning that life is more than a sum of its parts, and by applying advanced mathematical and computational principles to model and interpret life’s processes.

Research is currently being conducted in the following major thrust areas:

1) Microbial Systems Biology and Pathogenesis

A primary focus of research strength in the Center is in Microbial Systems. A cadre of over 25 Center scientists apply systems-based technologies to address microbial issues ranging through viral evolution and gene discovery, bacterial pathogenesis and genome sequencing, parasite functional and structural genomics, and global host response to invasion. Their research is recognized and supported by over $10 million in annual external funding by NIH, the USDA, the Wellcome Trust, the Gates Foundation, Howard Hughes, the Pew Trust, and other funding agencies that continue to place a priority on this research in the wake of the September 11, 2001, atrocities and subsequent biological terrorism.

Faculty using the tools of genomics, proteomics, and bioinformatics enhance existing programs in departments in the:

  • School of Medicine (Medicine, Infectious Disease, Microbiology and Immunology, Biochemistry and Molecular Biophysics, Biostatistics, Pharmacology, etc.)

  • School of Dentistry (Phillips Institute)

  • School of Pharmacy (Medicinal Chemistry, Institute for Structural Biology and Drug Development)

  • School of Humanities and Sciences (Biology and Chemistry)

  • McGuire VA Hospital (Medicine and Infectious Disease)

The Center has worked to nucleate this diverse group into a cohesive and highly collaborative research unit. Seven (7) new faculty have been recruited to this group through our collaborations with other research units. Scientifically, this unit is now clearly the strongest, most active, and most competitive of the Center research foci.

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Date last modified: 10/27/04
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