A. How
comfortable are you with the basic principles behind constructing
PSSMs? For example, could you have made Table 1B (Table of occurrences)
yourself?
B. How comfortable
are you about going from a table of occurences to a frequency table?
For example, could you have made Table 1C yourself?
C. How comfortable
are you about using a PSSM to score a sequence? For example, could you
have determined the values in the line marked "Score" of Table 2?
(Never mind pseudocounts for the moment)
| Comments
for questions II.A through II.C: |
|
A. How
comfortable are you with the notion of pseudocounts in the calculation
of PSSMs? Could you do such a calculation yourself?
B. How comfortable
are you with the notion of normalization with respect to overall
nucleotide frequencies? Could you do such a calculation yourself?
C. How comfortable
are you with the meaning and calculation of uncertainty and information
content?
| Comments
for questions III.A through III.C: |
|