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The members of the Tissue Repair Group, Drs. Sato-Bigbee, Diegelmann, Zehner, Beckmann, and Ratz, are studying how a variety of tissues respond to injury. Among these are smooth and cardiac muscle, bone, and brain tissues. The members of this group have expertise in signal transduction, the regulation of gene expression, and the biology of the extracellular matrix. The studies of this group are intended to better understand the endogenous healing processes of the body in hopes that these can be harnessed to promote more efficient and substantial wound healing in clinical settings.
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Robert Diegelmann, Professor: Regulation of collagen
deposition following tissue injury.
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Carmen Sato-Bigbee, Associate Professor
Regulatory pathways and
mechanisms of gene regulation during brain development and
regeneration, molecular mechanisms involved in oligodendrocyte
development and myelination.
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Matt Beckman, Assistant Professor:
Tissue engineering
approaches to diseases of bone, cartilage and connective
tissue; Regulation of osteoclastogenesis by steroid mediators,
matrix proteins, cytokines and growth factors.
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Paul Ratz, Professor:
Regulation of contraction of vascular
and bladder smooth muscles.
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Zendra Zehner, Professor:
Regulation of gene expression in
fibroblasts, macrophages and endothelial cells; Mechanisms
of transcriptional repression; Nuclear export and localization
of cytoskeletal mRNAs.
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Sarah Spiegel, Professor:
Role of sphingosine-1-phosphate in tissue repair and smooth muscle cell contraction and migration.
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Frank Fang, Assistant Professor:
The regulation of phospholipid
synthesis, metabolism and signaling in acute and chronic wound
healing.
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William Barton, Assistant Professor:
Regulation of angiogenesis during wound repair by the Angiopoietin-Tie2 receptor-ligand system.
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1101 E Marshall St | PO Box 980614 | Richmond, VA 23298 | ph 804.828.9762 | fax 804.828.1473
Site Update July 20, 2008, Responsible Unit - Department of Biochemistry & Molecular Biology, biochemgrad@mail.vcu.edu
Virginia Commonwealth University,
VCU School of Medicine
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