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The Neuroscience Group, Drs. Sato-Bigbee, Spiegel, Scarsdale, and Wright, are using biochemical, molecular, and structural approaches to understand the pathogenesis of alzheimer’s disease and multiple sclerosis and to elucidate the molecular signaling events that are essential for the growth and differentiation of oligodendrocytes and neurons. Much of their work is focused on understanding how neuronal cells sense changes in their environment and the molecular events that allow them to make appropriate responses to these changes. It is hoped that a more detailed understanding of these responses will provide insights into novel treatments for neuronal diseases.
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Carmen Sato-Bigbee, Associate Professor:
Regulatory pathways and mechanisms of gene regulation during brain development and regeneration, molecular mechanisms involved in oligodendrocyte development and myelination.
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J. Neel Scarsdale, Assistant Professor:
X-ray crystallography, protein engineering, protein folding and structures of serpins and
their roles in Alzheimer’s disease.
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H. Tonie Wright, Professor:
X-ray crystallography, protein
engineering, protein folding and structures of serpins and
their roles in Alzheimer’s disease.
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Sheldon Milstien, Professor:
Regulation of nitric oxide production
in neuronal development.
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Tomek Kordula, Associate Professor:
Regulation of gene
expression by proinflammatory cytokines in human
astrocytes.
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Jason Chen, Associate Professor:
G protein signaling in neurodegenerative diseases of the retina.
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Paul Dent, Professor:
Cytolysis of human glioma tumors by ionizing radiation.
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1101 E Marshall St | PO Box 980614 | Richmond, VA 23298 | ph 804.828.9762 | fax 804.828.1473
Site Update July 20, 2008, Responsible Unit - Department of Biochemistry & Molecular Biology, biochemgrad@mail.vcu.edu
Virginia Commonwealth University,
VCU School of Medicine
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