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The Inflammation/ Asthma Group consists of Drs. Spiegel, Barbour, Diegelmann, Ratz, Milstien, Larner, Bell, and Chalfant. The members of this group are studying biochemical, physiological, and immunological mechanisms in the inflammatory response. The expertise of this group includes macrophage biology, the biochemistry of the extracellular matrix, lipid signaling, and vascular physiology. Together, these investigators are elucidating the cellular and molecular mechanisms of inflammation in hopes of modulating this process to control asthma, periodontal disease, and allergy.
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Sarah Spiegel, Professor:
Mechanisms of sphingosine-1-phosphate
in mast and smooth muscle cell biology and allergy.
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Paul Ratz, Professor:
Contraction of smooth muscle cells.
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Suzanne Barbour, Professor:
Role of PLA2 and lipid
mediators in inflammation and innate and adaptive immune
responses.
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Robert Diegelmann, Professor:
Interaction of inflammatory
cells and components with collagen-producing cells during
tissue injury and repair.
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Charles Chalfant, Associate Professor:
Role of ceramide-1-
phosphate in prostanoid synthesis.
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Sheldon Milstien, Professor:
Mechanisms of sphingosine-1-
phosphate in mast and smooth muscle cell biology and allergy.
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Tomek Kordula, Associate Professor:
Role of inflammatory
cytokines and growth factors in deregulation of proteolytic balance
in human astrocytes.
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Jessica Bell, Assistant Professor:
Structural and biochemical analysis of protein:protein interactions in the inflammatory response upon activation of pathogen recognition receptors.
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Andrew Larner, Professor:
Type I and Type II interferon signaling. The Role of the Jak/Stat Signaling Pathway in Regulation of Gene Expression and Cell Metabolism.
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1101 E Marshall St | PO Box 980614 | Richmond, VA 23298 | ph 804.828.9762 | fax 804.828.1473
Site Update July 20, 2008, Responsible Unit - Department of Biochemistry & Molecular Biology, biochemgrad@mail.vcu.edu
Virginia Commonwealth University,
VCU School of Medicine
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