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The terms genomics, proteomics, and lipidomics refer to the systematic study of changes in gene expression, protein modification, and lipid mediators that occur in response to extracellular stimuli. Although most investigators in the Department of Biochemistry use these approaches in their research programs, the members of the Genomics/ Proteomics/ Lipidomics Group are at the forefront of the development and application of these technologies. These individuals, Drs. Spiegel, Sumitra Deb, Swati Deb, Beckman, Zehner, Kordula, Fang, Grogan, Roesser, Chen, and Milstien, are applying systems approaches to study important biological questions pertaining to cancer, heart disease, tissue repair and wound healing, and development.
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Sarah Spiegel, Professor:
Regulation of cell growth, motility,
apoptosis, angiogenesis and cancer by sphingolipid
metabolites.
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Sheldon Milstien, Professor:
Regulation of nitric oxide
production, neuronal development, and apoptosis
by sphingolipid metabolites.
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Swati Deb, Associate Professor:
Role of MDM2 and other
oncogenes in cell growth regulation and deregulation
using cell cycle analysis and proteomics.
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Sumitra Deb, Professor:
Microarray analysis of genes regulated
by wild type versus mutant p53.
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Tomek Kordula, Associate Professor:
Tissue-specific expression
of Serpin genes.
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W. McLean Grogan, Professor:
Properties and regulation of
cholesteryl ester hydrolases; cholesterol metabolism.
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Frank Fang, Assistant Professor:
Genetic overexpression or disruption of the LPA receptors in mice;
malignancy-associated alterations in cellular lipid composition and
functionality
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James Roesser, Assistant Professor:
RNA splicing, tissue-specific
regulation of calcitonin/ CGRP mRNA splicing, role of alternative
mRNA splicing in pathogensis of Neurofibromatosus type I
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Jason Chen, Associate Professor:
Impact of photoreceptor mutations on signal transduction in the visual system.
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Keith Baker,
Associate Professor:
Understanding the physiological role of nuclear hormone receptors; mechanisms of
regulated transcription; metabolic homeostasis. |
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1101 E Marshall St | PO Box 980614 | Richmond, VA 23298 | ph 804.828.9762 | fax 804.828.1473
Site Update July 20, 2008, Responsible Unit - Department of Biochemistry & Molecular Biology, biochemgrad@mail.vcu.edu
Virginia Commonwealth University,
VCU School of Medicine
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