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The Cardiovascular Disease/ Atherosclerosis Group consists of Drs. Zehner, Grogan, Gil, Barbour, Chalfant, Larner, and Ratz. The members of this group are using biochemical, molecular, and structural approaches to understand the pathogenesis of vascular disease. The research interests of this group include smooth muscle cell development and signaling, lipid hydrolase enzymology, lipoprotein structure and function, and macrophage/ foam cell biology. Hence the expertise of this group encompasses the broad spectrum of cells and tissues that are involved in cardiovascular disease. It is hoped that these synergistic studies will facilitate the development of novel mechanisms for treating one of the most prevalent diseases of the western world.
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Suzanne Barbour, Professor:
Role of PLA2 and lipid
mediators in membrane homeostasis and sterol metabolism.
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Paul Ratz, Professor:
Shock, vasospasm, hypertension.
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W. McLean Grogan, Professor:
Cholesteryl ester hydrolase role in
cholesterol metabolism and membrane structure.
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Zendra Zehner, Professor:
Regulation of gene expression
during cardiac and skeletal muscle development.
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Gregorio Gil, Professor:
Regulation of gene expression
by cholesterol and bile acids.
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Charles Chalfant, Associate Professor:
Role of macrophages
in inflammation leading to atherogenesis, signaling pathways
that mediate the release of eicosanoids and other
proinflammatory/ pro-atherogenic lipid mediators.
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Andrew Larner, Professor:
Stat3 and electron transport chain function in the heart. The Role of the Jak/Stat Signaling Pathway in Regulation of Gene Expression and Cell Metabolism.
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Keith Baker,
Associate Professor:
Understanding the physiological role of nuclear hormone receptors; mechanisms of
regulated transcription; metabolic homeostasis. |
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1101 E Marshall St | PO Box 980614 | Richmond, VA 23298 | ph 804.828.9762 | fax 804.828.1473
Site Update July 20, 2008, Responsible Unit - Department of Biochemistry & Molecular Biology, biochemgrad@mail.vcu.edu
Virginia Commonwealth University,
VCU School of Medicine
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