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Enoch P. Wei, Ph.D.
Associate Professor of Anatomy & Neurobiology and Internal Medicine
B.A., Chemistry, Univ. of North Carolina at Chapel Hill (1967)
Ph.D., Physiology, Univ. of North Carolina at Chapel Hill (1972)
| Office Address: | | Department of Anatomy & Neurobiology | | | | Virginia
Commonwealth University Medical Campus | | | | Box 980709 | | | | Richmond, VA 23298-0709 | | Office Phone: | | (804) 828-9705 |
| FAX: | | (804) 828-9477 | | e-mail: | | epwei@vcu.edu |
RESEARCH AND SCHOLARLY
INTERESTS
We have been studying the cerebral microcirculation in brain-injured animals equipped with cranial windows. We examined the cerebral vascular functions and the associated mechanisms following experimental traumatic brain injury (TBI). Our current projects focus on the development of possible posttraumatic therapy that can eliminate or minimize the damage caused by the secondary insults. So far we have demonstrated a time window after occurrence of TBI. The protection observed in acute experiments will be evaluated for its long-term effects in chronic experiments. In addition, we are probing a more proactive way in treating the animals with different TBI models. Hopefully the information generated from these studies will lead to better patient care in the future.
REPRESENTATIVE PUBLICATIONS
Kontos, H.A., and Wei, E.P. Endothelium-dependent responses after experimental brain
injury. J. Neurotrauma 9:349-354, 1992.
Wei, E.P., Kontos, H.A., and Beckman, J.S. Mechanism of cerebral vasodilation by
superoxide, hydrogen peroxide and peroxynitrite. Am. J. Physiol. 271:H1262-H1266, 1996.
Povlishock, J.T., Ueda, Y., and Wei, E.P. A review of the protective effects of
hypothermia on the axonal and vascular pathobiology associated with traumatic brain
injury. In: Hayashi, N., et al (eds): Hypothermia in acute brain damage. Springer-
Verlag Tokyo Berlin Heidelberg New York. pp. 19-23, 2004.
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