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Jeffery K. Taubenberger, M.D., Ph.D.
Senior Investigator
Laboratory of Infectious Diseases
B.A., Biology, George Mason University, (1982)
M.D., Medicine, Medical
College of Virginia, VCU, (1986)
Ph.D., Anatomy, Medical College of
Virginia, VCU, (1987)
Internship and Residency, Pathology, Laboratory
of Pathology, National Cancer Institute (1991)
Postdoctoral training,
National Cancer Institute
| Office Address: | | Laboratory of Infectious Diseases |
| | | National Institute of Allergy and Infectious Diseases National Institutes of Health |
| | | 33 NORTH DR RM 3E19A.2 MSC 3203
| | | | BETHESDA, MD 20892-3203 USA | | Office
Phone: | | (301) 443-5960 | | FAX: | | (301) 480-1696 | | e-mail: | | taubenbergerj@niaid.nih.gov |
RESEARCH AND SCHOLARLY INTERESTS
My laboratory has several interests which include: molecular genetics of
influenza and other RNA viruses; molecular genetic changes in lymphoma and
breast cancer; and developmental hematopoiesis. My clinical interest
involves application of molecular genetic techniques to diagnostic
pathology. Currently my laboratory is generating the complete genomic
sequence of the 1918 'Spanish' influenza virus using RNA from autopsy
tissues of 1918 influenza victims. The 1918 virus was responsible for a
global pandemic in 1918-1919 in which 40 million people died. Elucidating
the reasons for the incredible virulence of this virus has significant
public health application. We are also interested in the molecular genetic
basis for flu virus transmission between species. We have also
characterized novel morbilliviruses responsible for large scale die-offs of
dolphins and other marine mammals. In the field of cancer genetics, we have
recently concentrated on assessing loss of heterozygosity (LOH) as a screen
for genetic evolution in breast tumors by examining microdissected tissues
representing histologically definable stages of cancer. Finally, the
laboratory has interests in lymphocyte differentiation. We are
characterizing early stages of B cell development by examining the
expression of the novel surface marker, LIP-6. We have recently started a
project involved in a comprehensive analysis of gene expression in
developmentally defined stages of B-cell differentiation.
REPRESENTATIVE PUBLICATIONS
Reid, A.H., Fanning, T.G.,
Hultin, J.V. and Taubenberger, J.K. (1999) Origin and Evolution of the 1918
"Spanish" Influenza Virus Hemagglutinin. Proc. Natl. Acad. Sci.
96:1651-1656.
Taubenberger, J.K., Tsai. M.M., Fanning, T.G., Krafft, A.E., and
Lipsomb, T.P. (2000) Molecular genetic evidence for a novel morbillivirus
in a long-finned pilot whale (Globicephalus melas). Emerging Infectious
Diseases. Emerging Infec. Dis. 6:42045.
Lichy, J. H., Dalbegue, F., Zavar, M., Washington, C., Tsai, M. M.,
Sheng, Z.-M., Taubenberger, J. K. (2000) Genetic heterogeneity in ductal
carcinoma of the breast. Lab. Invest. 80:291-301.
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