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Thomas M. Reeves, Ph.D.
Associate Professor
B.A., Psychology Sangamon State University (1976)
M.A., Experimental Psychology, Sangamon State University (1978)
Ph.D., Developmental Biopsychology, Southern Illinois University (1984)
| Office Address: | | Department of Neurosurgery |
| | | Virginia Commonwealth University Medical Campus |
| | | Box 980629 |
| | | Richmond, VA 23298-0709 |
| Office Phone: | | (804) 828-9535 |
| FAX: | | (804) 828-9477 |
| e-mail: | | tmreeves@vcu.edu |
RESEARCH AND SCHOLARLY INTERESTS
Ongoing research conducted in Dr. Reeves' laboratory examines the electrophysiology of brain injury and recovery of function. His lab uses a variety of experimental models, including fluid percussion traumatic brain injury (TBI), deafferenting lesions, or a combination of these. Functional measures include intracellular and extracellular electrophysiological parameters, but an emphasis is placed on evoked extracellular field potentials, well suited to the study of brain injury. Among the findings from Dr. Reeves' lab are TBI-induced deficits in long-term potentiation (LTP), a cellular model of learning and memory. LTP deficits may be a particular instance of a general impairment to neuronal plasticity; for example, responses to paired-pulse stimulation also change after injury. Dr. Reeves collaborates with a multidisciplinary Neurotrauma Research Group at VCU/MCV, and this group has correlated the electrophysiological findings with behavioral, morphological, and molecular measures. In collaborations with clinical staff, Dr. Reeves has recorded EEG and single unit activity data from head injured patients, and quantitatively compared these electrophysiological measures with ions and neurotransmitters in the extracellular space.
REPRESENTATIVE PUBLICATIONS
Reeves, T.M., Phillips, L.L., Povlishock, J.T. Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and
functional recovery following traumatic brain injury. Experimental Neurology, 196, 126-139, 2005.
Reeves, T.M., Prins, M.L., Zhu, J-P, Povlishock, J.T., Phillips, L.L: Matrix metalloproteinase inhibition alters functional and
structural correlates of deafferentation-induced sprouting in the dentate gyrus. Journal of Neuroscience, 23, 10182-10189, 2003.
Phillips, L.L., & Reeves, T.M.: Interactive pathology following traumatic brain injury modifies hippocampal plasticity. Restorative
Neurology and Neuroscience, 19: 213-235, 2001.
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