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John T. Povlishock, Ph.D.
Professor & Chairman,
Department of Anatomy & Neurobiology
Professor of Neurological Surgery
Director of the
Commonwealth Center for the Study of Brain Injury
Co-Director of the
Neuroscience Center at Virginia Commonwealth University
B.S., Biology, Loyola College (1969)
M.S., Anatomy, Saint Louis University
(1971)
Ph.D., Anatomy, Saint Louis University (1973)
| Office Address: | | Department of Anatomy & Neurobiology | | | | Virginia
Commonwealth University Medical Campus | | | | Box 980709 | | | | Richmond, VA
23298-0709 | | Office
Phone: | | (804) 828-9623 |
| | | (804)828-9535 |
| FAX: | | (804) 828-9477 | | e-mail: | | jpovlishock@vcu.edu |
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RESEARCH AND SCHOLARLY INTERESTS
The work pursued in this laboratory focuses on traumatic brain injury in an
effort to better understand the initiating mechanisms that lead to brain damage.
Focusing on both traumatically induced vascular and axonal change, I employ
contemporary structural, functional, behavioral and cellular/molecular endpoints
to evaluate traumatically induced changes. Studies conducted, to date,
demonstrate progressive plasmalemmal and cytoskeletal change linked to the
activation of cysteine protease and free radical pathways. In my research, I have
trained over 25 pre- and postdoctoral students and we have reported our work in
over 160 manuscripts and chapters. Importantly, the work conducted in this
laboratory has resulted in the conduct of clinical trials for the treatment of
brain injured humans.
REPRESENTATIVE PUBLICATIONS
Buki, A., Okonkwo, O., Wang, K., and Povlishock, J. Cytochrome c release and
caspase activation in traumatic axonal injury. J. Neuroscience, 20(8) 2825-2834.
2000.
Buki, A., Siman, R., Trojanowski, J.A.,and Povlishock, J. The role of
calpain-mediated spectrin proteolysis in traumatically induced axonal injury. J.
of Neuropathology and Experimental Neurology 48(4) 365-375. 1999.
Okonkwo, D.O. and Povlishock, J.T. An intrathecal bolus of cyclosporin A before
injury preserves mitochondrial integrity and attenuates axonal disruption in
traumatic brain injury. J. of Cerebral Blood Flow and Metabolism 19:443-451,
1999.
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