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Andrew K. Ottens, Ph.D.
Assistant Professor
B.S., Chemistry, The College of New Jersey (1998)
Ph.D., Chemistry, University of Florida (2003)
Postdoctoral Training, Neuroscience, McKnight Brain Institute of the University of Florida
| Office Address: | | Department of Anatomy & Neurobiology | | | | Virginia
Commonwealth University Medical Campus | | | | Box 980709 | | | | Richmond, VA
23298-0709 | | Office
Phone: | | (804) 828-9477 | | FAX: | | (804) 828-9477 | | e-mail: | | akottens@vcu.edu |
RESEARCH AND SCHOLARLY INTERESTS
Brain injury and recovery processes involve multi-level molecular processes resulting in cellular dysfunction, survival and regeneration. Our lab is interested in understanding the molecular mechanisms, particularly at the protein level, involved in acute and chronic brain injury processes. Ongoing research is focused on molecular dynamics associated with brain changes due to neurotrauma (TBI and ischemia) and separately cigarette smoke exposure. We employ high-end chromatographic and mass spectrometry approaches to characterize quantitative and temporal protein dynamics in tissues to expand our knowledge of altered cellular processes. We are interested in relating such processes with functional outcome, diagnosis and potential treatment. We have a particular focus on proteolytic processes involved in cell death dynamics as well as changes in axonal function via altered synaptic and myelin proteins. Our lab is at the forefront of integrating novel analytical neuroproteomic approaches in neuroscience to explore the complex dynamics of the injured brain.
REPRESENTATIVE PUBLICATIONS
Ottens AK, Golden EC, Bustamante L, Hayes RL, Denslow ND, Wang KK. (2008) Proteolysis of multiple myelin basic protein isoforms after neurotrauma: Characterization by mass spectrometry. J. Neurochem. 104:1404-1414.
Ottens AK, Kobeissy FH, Fuller BF, Liu MC, Oli MW, Hayes RL, Wang KK. (2007) Novel neuroproteomic approaches to studying traumatic brain injury. Prog. Brain Res. 161:401-418.
Ottens AK, Kobeissy FH, Wolper RA, Haskins WE, Hayes RL, Denslow ND Wang KK (2005) A multidimensional differential proteomic platform using dual-phase ion-exchange chromatography-polyacrylamide gel electrophoresis/reversed-phase liquid chromatography tandem mass spectrometry. Anal. Chem. 77:4836-4845.
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