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Richard J. Krieg, Jr., Ph.D.
Professor of Anatomy & Neurobiology and Pediatrics
B.S., Biology, University of San Francisco (1967)
M.S., Human Anatomy, University of California at Davis (1969)
Ph.D., Anatomy University of California at Los Angeles (1975)
| Office Address: | | Department of Anatomy & Neurobiology |
| | | Virginia Commonwealth University Medical Campus |
| | | Box 980709 |
| | | Richmond, VA 23298-0709 |
| Office Phone: | | (804) 828-9540 |
| FAX: | | (804) 828-9477 |
| e-mail: | | krieg@vcu.edu |
RESEARCH AND SCHOLARLY INTERESTS
Central nervous system control of pituitary gland secretion is my research interest. Our focus is on growth and growth hormone (GH) secretion and reproduction and luteinizing hormone (LH) secretion. We are attempting to find out why growth fails in children with renal insufficiency and why reproductive function is compromised in women withkidney disease. We use blood sampling techniques in freely behaving animals to see what happens to GH and LH secretion in animals with renal insufficiency. To find out what effects are due to changes in the pituitary gland itself, we study "en masse" secretion by pituitary cells in a system called "perifusion of dispersed pituitary cells". We can also study hormone secretion by individual cells using a system called "reverse hemolytic plaque assay". If we know what is happening to hormone secretion in the awake animal, and know what effects are due to changes in pituitary gland cells, we can extrapolate what is wrong with brain control of pituitary hormone secretion. We study brain and target tissues using molecular techniques like RNAse protection assay and RT-PCR.
REPRESENTATIVE PUBLICATIONS
Krieg Jr., R.J., Tokieda K., Veldhuis, J.D., Chan, J.C.M.: Impact of
uremia on female reproductive cyclicity, ovulation, and luteinizing
hormone in the rat. Kidney International 58:569-574, 2000.
Moulas, A.N., Krieg Jr., R.J., Veldhuis, J.D., Chan, J.C.M.: Effect of
the growth hormone (GH) secretagogue L-163,255 and restricted feeding
time on GH pulsatility in the rat. European Journal of Endocrinology
147:143-148, 2002.
Rege, B., Krieg, R., Gao, N., Sarkar, M.A. Down-Regulation of Hepatic
CYP3A in Chronic Renal Insufficiency. Pharmaceutical Research
20:1600-1606, 2003.
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