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Kimberle Jacobs, Ph.D.
Assistant Professor
B.A., Psychology, University of Delaware (1986)
Ph.D., Neuroscience, Brown University (1994)
Postdoctoral training at Stanford University Medical School (1994 - 1998)
Research Associate Stanford University Medical School (1998 - 2001)
| Office Address: | | Department of Anatomy | | | | Virginia
Commonwealth University Medical Campus | | | | Box 980709 | | | | Richmond, VA 23298-0709 | | Office Phone: | | (804)
827-2135 | | FAX: | | (804) 828-9477 |
| e-mail: | | kmjacobs@vcu.edu |
RESEARCH AND SCHOLARLY INTERESTS
Work in my laboratory seeks to identify cortical elements and circuitry that
contribute to plasticity of the nervous system, including alterations in synaptic
strengths, cellular differentiation and neuronal excitability. We currently employ a
model of developmental epilepsy to understand the mechanisms of hyperexcitibility
induced by early brain damage. This model is both clinically relevant and
experimentally useful in determining how normal rules of development may produce a
functionally abnormal cortex. Using a combination of patch-clamping, field
potentials, single cell aRNA amplification, immunohistochemistry and anatomical
techniques we explore how modifications in particular cell types contribute to
overall changes in functional circuitry.
REPRESENTATIVE PUBLICATIONS
Jacobs, K. M., Graber, K. D., Kharazia, V. N., Parada, I., and Prince, D. A. (2000)
Postlesional Epilepsy: The Ultimate Brain Plasticity. Epilepsia, 41: S153-161.
Jacobs, K. M., Kharazia, V. N., and Prince, D. A. (1999) Mechanisms underlying
epileptogenesis in cortical malformations. Epilepsy Research, 36: 165-188.
Jacobs, K. M., Hwang, B. J., and Prince, D. A. (1999) Focal epileptogenesis in a
rat model of polymicrogyria. Journal of Neurophysiology, 81: 159-173.
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