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M. Ross Bullock, M.D., Ph.D.
Reynolds Professor and Director of Neuroscience Intensive Care
Division of Neurosurgery, Virginia Commonwealth University
M.D., Birmingham University, England - M.D.
Ph.D., Neuroscience, University of Natal - Ph.D.
| Office Address: | | Department of Surgery |
| | | Virginia Commonwealth University Medical Campus |
| | | Box 980631 |
| | | Richmond, VA 23298-0631 |
| Office Phone: | | (804) 828-1357 |
| FAX: | | (804) 828-0034 |
| e-mail: | | robullock@hsc.vcu.edu |
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RESEARCH AND SCHOLARLY INTERESTS
CLINICAL - Clinical studies involve microdialysis and multi-parameter monitoring of the acutely injured brain to determine factors responsible for secondary brain damage in trauma, stroke and subarachnoid hemorrhage. New techniques for brain oxygen, PaCO2 and microdialysis are being used together with blood flow mapping. Current studies are focused upon demonstrating glutamate release,and penetration of neuroprotective drugs into the injured brain, and effect of cyclosnonin A and oxygen delivery enhancement.
RESEARCH TRAUMA - We are using continuous focal "metabolic monitoring" to determine thresholds for tissue damage to demonstrate harmful mechanisms, and synergistic interplay between different potentially toxic neurotransmitter substances and free radicals, employing receptor autoradiography 2-deoxyglucose and iodoantipyrine autoradiography and microdialysis. are used. We are investigating a therapeutic role for lactate after brain injury.
STROKE - The feline and rat middle cerebral artery occlusion models are used to explore the neuroprotective effects of compounds which enhance oxygen transport and how these may be employed together with other neuroprotective strategies. MRI spectroscopy and diffusion-weighted imaging are being used to test the hypothesis that ultra early detection of ischemia may be achieved using DWI, before cell viability is lost. In human intra-cenehial hematoma and we are evaluating the role of RTPA for clot lysis.
REPRESENTATIVE PUBLICATIONS
Chen T., Qian Y.Z., Di X., Rice A., Zhu J.P., Bullock R. 2000. Lactate/glucose dynamics after rat fluid percussion brain injury. J Neurotrauma., 17:135-42
J Neurotrauma 2000 Jan;17(1):101-12
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Levasseur J.E., Alessandri B., Reinert M., Bullock R., Kontos H.A. 2000. Fluid percussion injury transiently increases then decreases brain oxygen consumption in the rat. J Neurotrauma., 17:101-12.
Al-Samsam R.H., Alessandri B., Bullock R. 2000. Extracellular N-acetyl-aspartate as a biochemical marker of the severity of neuronal damage following experimental acute
traumatic brain injury. J Neurotrauma. 17:31-9.
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