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William C. Broaddus, M.D., Ph.D
Associate Professor, primary appointment in the Division of Neurosurgery
B.A., Biochemistry, Cornell University (1975)
Ph.D., Case Western Reserve University (1982)
M.D., Case Western Reserve University (1984)
Residency and Post-doctoral training in Surgery and Neurosurgery at the University of Virginia School of Medicine
| Office Address: | | Department of Surgery |
| | | Virginia Commonwealth University Medical Campus |
| | | Box 980709 |
| | | Richmond, VA 23298-0709 |
| Office Phone: | | (804) 828-2395 |
| FAX: | | (804) 828-9477 |
| e-mail: | | wbroaddu@vcu.edu |
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RESEARCH AND SCHOLARLY INTERESTS
- Gene therapy strategies using adenovirus vectors to overexpress antitumor genes in malignant gliomas.
- Antisense oligonucleotide (ODN) strategies for disrupting expression of molecular components critical for glioma cell proliferation and malignant behavior.
- Investigation of the role of extracellular matrix components, particularly matrix metalloproteinases, in glioma cell proliferation, motility and invasiveness.
- Use of direct intraparenchymal controlled-rate infusion to deliver macromolecular and particulate therapeutic agents into the central nervous system.
- Neuroimaging/computer-assisted surgery.
- Clinical research in the management of patients with brain tumors.
REPRESENTATIVE PUBLICATIONS
Prabhu SS, Broaddus WC, Gillies GT, Loudon W, Chen ZJ, Greenwald B, Smith B: Distribution of macromolecular dyes in brain using positive pressure infusion: a model for direct, wide-spread
delivery of therapeutic agents. Surgical Neurology 50: 367-375, 1998.
Broaddus WC, Prabhu SS, Gillies GT, Neal DJ, Chen ZJ, Fillmore H, Young HF: Distribution and stability of antisense phosphorothioate oligonucleotides in rodent brain following direct
intraparenchymal controlled-rate infusion. J. Neurosurgery 88: 734-742, 1998.
Broaddus WC, Prabhu SS, Wu-Pong S, Gillies GT, Fillmore H: Design and delivery of antisense oligonucleotide strategies in the central nervous system. In, Phillips MI (ed): Methods in Enzymology: Antisense Techniques. vol. 314, pp. 121-135, Abelson JN, Simon, MI (series editors), 2000.
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